Palomid 529
CAS No. 914913-88-5
Palomid 529 ( Palomid 529; Palomid-529; Palomid529 )
Catalog No. M17658 CAS No. 914913-88-5
Palomid 529 has been used in trials studying the treatment of Age-Related Macular Degeneration.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 42 | In Stock |
|
10MG | 61 | In Stock |
|
25MG | 120 | In Stock |
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50MG | 222 | In Stock |
|
100MG | 368 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
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Biological Information
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Product NamePalomid 529
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NoteResearch use only, not for human use.
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Brief DescriptionPalomid 529 has been used in trials studying the treatment of Age-Related Macular Degeneration.
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DescriptionPalomid 529, also known as P529, is a novel PI3K/Akt/mTOR inhibitor. Palomid 529 (P529) inhibits the TORC1 and TORC2 complexes and shows both inhibition of Akt signaling and mTOR signaling similarly in tumor and vasculature. It was demonstrated that P529 inhibited tumor growth, angiogenesis, and vascular permeability. It retained the beneficial aspects of tumor vascular normalization that rapamycin boasts. However, P529 showed the additional benefit of blocking pAktS473 signaling consistent with blocking TORC2 in all cells and thus bypassing feedback loops that lead to increased Akt signaling in some tumor cells.
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SynonymsPalomid 529; Palomid-529; Palomid529
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PathwayOthers
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TargetOther Targets
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RecptormTORC1; mTORC2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number914913-88-5
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Formula Weight406.43
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Molecular FormulaC24H22O6
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Purity98%
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SolubilityDMSO : 20.5 mg/mL. 50.44 mM;
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SMILESCOc1ccc(COc2c(OC)cc3c(oc(=O)c4c3ccc(c4)C(C)O)c2)cc1
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Chemical Name8-(1-hydroxyethyl)-2-methoxy-3-((4-methoxybenzyl)oxy)-6H-benzo[c]chromen-6-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Xue Q, et al. Y Res, 2008, 68(22), 9551-9557.
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