Palomid 529

CAS No. 914913-88-5

Palomid 529 ( Palomid 529; Palomid-529; Palomid529 )

Catalog No. M17658 CAS No. 914913-88-5

Palomid 529 has been used in trials studying the treatment of Age-Related Macular Degeneration.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 42 In Stock
10MG 61 In Stock
25MG 120 In Stock
50MG 222 In Stock
100MG 368 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Palomid 529
  • Note
    Research use only, not for human use.
  • Brief Description
    Palomid 529 has been used in trials studying the treatment of Age-Related Macular Degeneration.
  • Description
    Palomid 529, also known as P529, is a novel PI3K/Akt/mTOR inhibitor. Palomid 529 (P529) inhibits the TORC1 and TORC2 complexes and shows both inhibition of Akt signaling and mTOR signaling similarly in tumor and vasculature. It was demonstrated that P529 inhibited tumor growth, angiogenesis, and vascular permeability. It retained the beneficial aspects of tumor vascular normalization that rapamycin boasts. However, P529 showed the additional benefit of blocking pAktS473 signaling consistent with blocking TORC2 in all cells and thus bypassing feedback loops that lead to increased Akt signaling in some tumor cells.
  • Synonyms
    Palomid 529; Palomid-529; Palomid529
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    mTORC1; mTORC2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    914913-88-5
  • Formula Weight
    406.43
  • Molecular Formula
    C24H22O6
  • Purity
    98%
  • Solubility
    DMSO : 20.5 mg/mL. 50.44 mM;
  • SMILES
    COc1ccc(COc2c(OC)cc3c(oc(=O)c4c3ccc(c4)C(C)O)c2)cc1
  • Chemical Name
    8-(1-hydroxyethyl)-2-methoxy-3-((4-methoxybenzyl)oxy)-6H-benzo[c]chromen-6-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Xue Q, et al. Y Res, 2008, 68(22), 9551-9557.
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